Polymyxin B

Antibiotics

Polymyxin B
  • Brand logo & Packshot - Pobix™ 500,000 Units.
  • Composition - Each vial contains Polymyxin B Sulphate USP equivalent to Polymyxin B 5,00,000 Units.
  • Description - Polymyxin B Sulfate is one of a group of basic polypeptide antibiotics derived from B polymyxa (B aerosporous). Polymyxin B sulfate is the sulfate salt of Polymyxins B1 and B2, which are produced by the growth of Bacillus polymyxa (Prazmowski) Migula (Fam. Bacillacea).
  • Indications & Usage - Acute Infections Caused by Susceptible Strains of Pseudomonas aeruginosa. Polymyxin B sulfate is a drug of choice in the treatment of infections of the urinary tract, meninges and bloodstream caused by susceptible strains of Ps. aeruginosa. It may also be used topically and subconjunctivally in the treatment of infections of the eye caused by susceptible strains of Ps. aeruginosa. It may be indicated in serious infections caused by susceptible strains of the following organisms, when less potentially toxic drugs are ineffective or contraindicated - H influenzae, specifically meningeal infections. Escherichia coli, specifically urinary tract infections. Aerobacter aerogenes, specifically bacteremia. Klebsiella pneumoniae, specifically bacteremia.
  • Dosage & administration - Intravenous Administration: Dissolve 500,000 Polymyxin B units in 300 to 500 mL solutions for parenteral dextrose injection 5 percent for continuous drip. Adults and children - 15,000 to 25,000 units/kg body weight/day in individuals with normal kidney function. This amount should be reduced from 15,000 units/kg downward for individuals with kidney impairment. Infusions may be given every 12 hours; however, the total daily dose must not exceed 25,000 units/kg/day. Infants - Infants with normal kidney function may receive up to 40,000 units/kg/day without adverse effects.
  • Storage conditions - Store below 25°C, excursion permitted to 15°C to 30°C. Protect from light.