Antibiotics
Meropenem & Sulbactam
- Brand logo & Packshot - Mepecon-SB™ 1.5 gm.
- Composition - Each vial contains Meropenem IP equivalent to anhydrous Meropenem 1000 mg, sterile Sulbactum sodium IP 500 mg is added as buffer.
- Description - Meropenem is a broad-spectrum carbapenem antibiotic. The bactericidal activity of Meropenem results from the inhibition of cell wall synthesis. Meropenem readily penetrates the cell wall of most Gram-positive and Gram-negative bacteria to reach penicillin-binding-protein (PBP) targets. Sulbactam is a β-lactamase inhibitor. This drug is given in combination with β-lactam antibiotics to inhibit β-lactamase, an enzyme produced by bacteria that destroys the antibiotics. Sulbactam in the Meropenem and Sulbactam for Injection formulation effectively extends the antibiotic spectrum of Meropenem to include many bacteria normally resistant.
- Indications & Usage - Mepecon-SB is indicated for the treatment of the following infection when caused by susceptible isolates of the designated microorganisms: For the treatment of lower respiratory tract infection caused by gram negative bacteria in adults only.
- Dosage & administration - Adults: The recommended dose of Mepecon SB is 1.5 gm (1 gm Meropenem + 500 mg sulbactam) given every 8 hourly. Mepecon SB should be administered by intravenous infusion over approximately 15 to 30 minutes & intravenous bolus injection over approximately 3-5 minutes. Adults with Renal Impairment: Dosage should be reduced in patients with creatinine clearance less than 51 mL/min.
- Storage conditions - Store below 25°C protected from light & moisture. Do not allow to freeze.