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Contract Research & Manufacturing

Concord is providing Contract Research & Manufacturing services in the area of fermentation and semi-synthesis products.

The R&D facility is certified by DSIR (Department of Science & Industrial Research) INDIA. It comprises of three divisions:

  • R&D Fermentation
  • R&D Chemical Synthesis
  • Analytical Development Laboratory.

R&D Fermentation: It is equipped with facility for isolation of strain, mutation & passive selection of microbial strains; shake flask facility for strain improvement, laboratory fermenters and pilot plant facility for scale-up of fermentation process. Contract research and manufacturing services in the area of fermentation are as below:

  • Strain Improvement program to significantly increase the titer of the target product and/or improve its impurity profiling.
  • Media Optimization: Use of cost effective locally sourced media of Client to increase the overall process productivity
  • Process Development by optimizing the process control during process scale up to have an efficient high throughput that is also cost effective.
  • Process Scale-up from shake flask to Pilot and Commercial scale
  • Development of optimized biotransformation processes.
  • Continuous process improvement

R&D Chemical Synthesis: Chemical R&D has state of the art facility for extraction, isolation and purification of product from upstream (fermentation) process. The facility is having a scaled down version of all the major equipments at plant, thus giving high flexibility during process scale up. R&D facility is equipped with all essential equipments for complex organic synthesis chemistry. Some of the major equipments are various filtration units like Micro filtration, Ultra filtration and Nano filtration, SS-316 reactors, Rotavapour, Hydrogenater, Preparative HPCL, Open column chromatography, Flash chromatography, various drying and filtration systems.

Some of the major activities at Chemical R&D are:

  • Development of Downstream process to support upstream process
  • Process optimization and scale up of processes from R&D to pilot and commercial.
  • Continuous process improvement to improve the overall process yield and have a cost effective process.

R&D Analytical: The R&D facility is well supported by Analytical Development Lab which is equipped with instruments like HPLC, UPLC, GC, GC-HS, LCMS and other supporting equipments required for testing.

The analytical laboratory carries out the following operations:

  • Development/Validation and transfer of analytical method for in process and final product as per regulatory requirements.
  • Synthesis, Isolation and characterization of process impurities.

The Competitive advantages of having Concord has a CRAM partner:

  • Experience with diverse strain like Streptomycetes, Bacteria, Fungi, E.coli etc as well as numerous biocatalyst classes.
  • Strong expertise in manufacturing of niche complex biotechnology products
  • Necessary infrastructure to scale up process from R&D to pilot and commercial.
  • The research team comprises of senior scientists with Ph.D., Microbiologists & Biotechnologists who have rich experience in the field of Biotechnology and its downstream process ensuring that the project is completed in a time bound manner.
  • Dedicated teams for projects
  • R&D well supported by analytical and regulatory support.
  • Competitive pricing
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